Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

This study is testing a combination of disulfiram (a drug usually used for alcohol dependence) with copper gluconate and liposomal doxorubicin (a chemotherapy) for people with sarcoma — a type of cancer affecting bones, muscles, or connective tissues — that has returned or stopped responding to previous treatments. **You may be eligible if...** - You have been confirmed to have relapsed or treatment-resistant sarcoma - You have measurable disease that can be evaluated on scans - You are generally able to function and care for yourself (Karnofsky/Lansky score of 50% or higher) - Your blood counts and organ function are within acceptable ranges - You are able to swallow pills **You may NOT be eligible if...** - You have an active, uncontrolled infection - You have an allergy to any of the study drugs or copper (including Wilson's Disease) - You are enrolled in another cancer treatment trial - You consume alcohol (you must abstain during the study) - You have a serious psychiatric or medical condition Talk to your doctor to see if this trial is right for you.