RecruitingPhase 2NCT05214820

68Ga-PSMA PET Imaging of Upper Metastatic Gastric Cancers to Determine Eligibility to Endoradiotherapy

Clinical Assessment of the Therapeutic Potential of 177Lu-PSMA Endoradiotherapy for the Treatment of Upper Metastatic Gastric Cancers Using 68Ga-PSMA PET-based Dosimetry


Sponsor

Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Enrollment

20 participants

Start Date

Jan 17, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Upper gastrointestinal (GI) cancers are a major health problem in Canada. At the metastatic stage, options are limited (usually chemotherapy, immunotherapy, personalized therapies under research protocols). These options are not applicable to all patients and may have significant toxicities. Endoradiotherapy (ERT) using a radioisotope coupled with a localization vector specifically targeting tumor cells to deliver a localized dose of radiation therapy is a promising avenue as it can treat disseminated neoplastic disease in a specific manner sparing healthy tissue with minimal side effects. The main goal of this study is to confirm that patients with upper GI cancer would be eligible for ERT (177Lu-PSMA treatment by using 68Ga-PSMA PET/CT assessment).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a specialized PET scan using a radioactive tracer called 68Ga-PSMA (normally used for prostate cancer imaging) can detect upper gastrointestinal cancers and help determine which patients might benefit from targeted radiation therapy (called endoradiotherapy). These cancers include esophageal, stomach, bile duct, and pancreatic adenocarcinomas. **You may be eligible if...** - You are 18 years old or older - You have active adenocarcinoma of the esophagus, stomach, bile ducts, or pancreas confirmed by CT scan within the last 8 weeks - You are able to give informed consent - The PSMA PET scan can be performed within 2 months of your qualifying CT scan **You may NOT be eligible if...** - You have another active cancer (other than non-melanoma skin cancer) - Your performance status is too low (ECOG score greater than 3) - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALRadiopharmaceutical 68Ga-PSMA

Injection of 68Ga-PSMA followed by 3 PET/CT acquisitions


Locations(1)

CIUSSS de l'Estrie- CHUS Hospital

Sherbrooke, Quebec, Canada

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NCT05214820