Screening Women With Prior HPV for Anal Neoplasia

This study is screening women who have had high-grade genital HPV-related precancerous conditions or cancers for anal cancer precursors (called anal neoplasia). HPV infections that cause cervical or vulvar disease can also cause similar problems in the anal area, but this is often overlooked in clinical care. **You may be eligible if...** - You are a woman aged 35 or older - You have a documented history of high-grade cervical, vulvar, or vaginal precancerous lesions (CIN2+, VIN2+, VAIN2+) or non-metastatic cervical, vaginal, or vulvar cancer - You have tested negative for HIV - You are a patient at Mount Sinai Health System (New York) or Harris Health System (Houston) - You speak English or Spanish **You may NOT be eligible if...** - You have previously had a high-resolution anoscopy (a procedure to examine the anal canal) Talk to your doctor to see if this trial is right for you.