Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ

This study is testing whether cryoablation — a minimally invasive procedure that uses extreme cold to destroy abnormal tissue — can be used instead of surgery for women with a small area of ductal carcinoma in situ (DCIS), a non-invasive form of breast cancer confined to the milk ducts. **You may be eligible if...** - You have been diagnosed with DCIS measuring 2 cm or less (confirmed by biopsy) - You have no prior history of DCIS or invasive breast cancer in the same breast - You have not had prior surgical biopsy or lumpectomy in the same breast - You have enough breast volume for the procedure to be safely performed - You are not pregnant or breastfeeding and have not been pregnant in the past 6 months **You may NOT be eligible if...** - You have had previous radiation to the same breast - You have a breast that is too small for safe cryoablation - You have a history of invasive breast cancer Talk to your doctor to see if this trial is right for you.