RecruitingPhase 2NCT05223803

TERPS Trial for de Novo Oligometastic Prostate Cancer

Phase 2 Randomized Total Eradication of Metastatic Lesions Following Definitive Radiation to the Prostate in de Novo oligometaStatic Prostate Cancer (TERPS) Trial


Sponsor

University of Maryland, Baltimore

Enrollment

122 participants

Start Date

Oct 18, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether treating all visible tumor spots (called oligometastases) with targeted radiation or ablation — in addition to standard hormone therapy — can improve outcomes for men with newly diagnosed prostate cancer that has spread to a small number of sites. **You may be eligible if...** - You have newly diagnosed prostate cancer that has spread to 1–3 bone or soft tissue sites (with at least one in bone), identified within the past 6 months - You have no symptoms from the metastases - All tumor sites are visible on imaging - You can receive hormone therapy (androgen deprivation therapy) **You may NOT be eligible if...** - You have more than 3 metastatic sites (or more than 5 on advanced imaging) - Your cancer has spread to certain areas that cannot be safely treated with radiation - You have had prior treatment for prostate cancer metastases Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONProstate radiation (XRT)

Both arms will receive prostate radiation. Multiple treatment regimens are allowed per protocol.

DRUGSystemic Therapy

All systemic therapy is provided as best prescribed for patient per their medical oncologist.

RADIATIONStereotactic ablative radiation therapy (SABR)

SABR is delivered to those randomized to Arm 2.


Locations(9)

UC San Diego Moores Cancer Center

La Jolla, California, United States

Maryland Proton Treatment Center

Baltimore, Maryland, United States

UMMC

Baltimore, Maryland, United States

Upper Chesapeake Health

Bel Air, Maryland, United States

Central Maryland Radiation Oncology

Columbia, Maryland, United States

Baltimore Washington Medical Center

Glen Burnie, Maryland, United States

Sidney Kimmel Cancer Center at Jefferson Health

Philadelphia, Pennsylvania, United States

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

Bon Secours Cancer Institute at St. Francis

Midlothian, Virginia, United States

View Full Details on ClinicalTrials.gov

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NCT05223803


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