RecruitingNot ApplicableNCT05224726

Platelet Rich Plasma for Uterine Scar

Platelet Rich Plasma for the Treatment of Uterine Scar

Sponsor

The University of Texas Health Science Center, Houston

Enrollment

40 participants

Start Date

Jul 19, 2025

Study Type

INTERVENTIONAL

Conditions

Uterine Bleeding Pelvic Pain Cesarean Section Complications Menstrual Irregularity

Summary

When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 52 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether platelet rich plasma (PRP) — a substance made from your own blood — can help heal the uterine scar made during a cesarean (C-section) delivery. Researchers want to see if applying PRP to the uterine incision during a planned C-section improves healing. You may be eligible if... - You are a woman who is having a planned (elective) cesarean delivery - You are at least 37 weeks pregnant (full term) - You are between 18 and 52 years old You may NOT be eligible if... - You have a low platelet count (below 70,000) - You have a connective tissue disease - You have uterine scars from other surgeries (such as fibroid removal) - You have an abnormally shaped uterus (unicornuate, bicornuate, or didelphic) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPlatelet Rich Plasma

Injection of 5cc of PRP preparation at the myometrium around the uterine incision after it has been sutured.

OTHERPlacebo

Injection of 5cc of 0.9% Normal Saline at the myometrium around the uterine incision after it has been sutured.

Locations(1)

Sheba Medical Center

Ramat Gan, Center, Israel

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NCT05224726

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