Platelet Rich Plasma for Uterine Scar
Platelet Rich Plasma for the Treatment of Uterine Scar
The University of Texas Health Science Center, Houston
40 participants
Jul 19, 2025
INTERVENTIONAL
Conditions
Summary
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.
Eligibility
Inclusion Criteria2
- Women undergoing elective cesarean delivery
- Term pregnancy (≥37 weeks of gestation)
Exclusion Criteria4
- Thrombocytopenia (CBC Platelet count \<70,000)
- Connective tissue disease
- Uterine scars other than cesarean (s/p myomectomy, s/p cornual resection)
- Malformed uterus (unicornuate, bicornuate, didelphic)
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Interventions
Injection of 5cc of PRP preparation at the myometrium around the uterine incision after it has been sutured.
Injection of 5cc of 0.9% Normal Saline at the myometrium around the uterine incision after it has been sutured.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05224726