RecruitingPhase 2NCT05231122

Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer

Randomized Phase 2 Clinical Trial of Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 in Patients With Recurrent Ovarian Cancer


Sponsor

Roswell Park Cancer Institute

Enrollment

80 participants

Start Date

Mar 12, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial tests whether pembrolizumab combined with bevacizumab with or without agonist anti-CD40 CDX-1140 works to shrink tumors in patients with ovarian cancer that has come back (recurrent). Anti-CD40 CDX-1140 works by stimulating certain immune cells within the tumor and, when combined with other immunotherapy treatments, may increase antitumor antibody production. Immunotherapy with monoclonal antibodies, such as pembrolizumab and bevacizumab, may help the body's immune system, and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab and bevacizumab with anti-CD40 CDX-1140 may decrease symptoms, prolong survival, and improve quality of life in patients with ovarian cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination of immunotherapy drugs — pembrolizumab and bevacizumab, with or without an immune-activating drug called CDX-1140 — for women with recurrent ovarian, fallopian tube, or peritoneal cancer that has come back after prior treatment. **You may be eligible if...** - You are 18 or older - You have recurrent serous (low or high grade), endometrioid, or clear cell ovarian, fallopian tube, or primary peritoneal cancer - Your cancer has come back after previous treatment (either platinum-sensitive or platinum-resistant) - You have had no more than 4 prior lines of treatment - Your BRCA gene mutation status is known **You may NOT be eligible if...** - You have had more than 4 prior lines of treatment - You have untreated brain metastases - You have serious autoimmune disease requiring steroids or immunosuppressants - You have uncontrolled high blood pressure or significant bleeding history (due to bevacizumab) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALAnti-CD40 Agonist Monoclonal Antibody CDX-1140

Given IV

BIOLOGICALBevacizumab

Given IV

BIOLOGICALPembrolizumab

Given IV

OTHERQuality-of-Life Assessment

Ancillary studies

OTHERQuestionnaire Administration

Ancillary studies


Locations(2)

Roswell Park Cancer Institute

Buffalo, New York, United States

M D Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05231122


Related Trials