Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
University Hospital Center of Martinique
465 participants
Apr 9, 2021
INTERVENTIONAL
Conditions
Summary
In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .
Eligibility
Inclusion Criteria4
- Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique)
- Sporadic or familial form
- Informed with a written consent signed by the participant and the investigator
- Affiliate or beneficiary of french social security.
Exclusion Criteria3
- Patient who is not of African descent
- Refusal to participate.
- Patients not affiliated to french social security
Interventions
Identify the Allelic frequency of the HOXB13 c.853delT mutation in patients with a cancer prostate in Martinique
Locations(1)
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NCT05231915