Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT

This trial compares two approaches for patients with lung cancer (NSCLC) that has spread to the brain but is not causing symptoms: immediate radiation to the brain versus watchful waiting (observation) while taking targeted pills. Researchers want to know if delaying radiation is just as safe. **You may be eligible if...** - You have been diagnosed with NSCLC that has a specific gene mutation (EGFR or ALK) - You have brain metastases confirmed on imaging that are not causing symptoms - You are in reasonably good health (ECOG performance status 0–2) - You are willing to follow-up on the study schedule **You may NOT be eligible if...** - You have only cancer cells in the fluid around the brain (no actual brain lesion) - Your cancer has spread to the brainstem - You have already had radiation to the brain - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.