RecruitingNCT05240885

Metabolic and Functional Consequences of Aging in Health and Disease

Sponsor

Texas A&M University

Enrollment

100 participants

Start Date

Mar 4, 2022

Study Type

OBSERVATIONAL

Conditions

Aging

Summary

Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.

Eligibility

Min Age: 50 Years

Inclusion Criteria5

Stable body-weight (± 5%) for the past 3 months
Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
Ability to walk, sit down and stand up independently or with walking mobility aids
Ability to lie in a supine or elevated position for up to 3 hours
Willingness and ability to comply with the protocol

Exclusion Criteria9

Insulin dependent diabetes mellitus
Established diagnosis of malignancy
History of untreated metabolic diseases including hepatic or renal disorder
Presence of acute illness or metabolically unstable chronic illness
Presence of fever within the last 3 days
Use of short course of oral corticosteroids within 4 weeks preceding study day
Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
(Possible) pregnancy
Already enrolled in another clinical trial and that clinical trial interferes with participating in this study