RecruitingNot ApplicableNCT05258396

Exploring Cortical Remyelination in Children With Multiple Sclerosis

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

40 participants

Start Date

Aug 11, 2022

Study Type

INTERVENTIONAL

Conditions

Children With Multiple Sclerosis

Summary

Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.

Eligibility

Min Age: 12 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using special MRI brain scans to look at whether the protective coating around nerve cells (called myelin) in the brain's outer layer can repair itself in children with multiple sclerosis (MS). Understanding this process could help develop better treatments for young people with MS. **You may be eligible if...** - You are between 12 and 18 years old - You have been diagnosed with relapsing-remitting MS - You have not had a relapse in the last 4 weeks - You have not received steroid treatment in the last 4 weeks - Healthy volunteers aged 12–18 without neurological conditions are also eligible **You may NOT be eligible if...** - You have a device in your body that is incompatible with MRI (such as a pacemaker) - You have a tattoo on your face that may cause problems with MRI - You are claustrophobic - You are pregnant or have a copper intrauterine device (IUD) - A parent or guardian refuses to give consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMRI without injection of contrast product

MRI without injection of contrast product

Locations(3)

Service de Neurologie Pédiatrique, Hôpital du Kremlin Bicêtre

Le Kremlin-Bicêtre, France

CIC Neurosciences - Pitié Salpêtrière

Paris, France

Service de Neurologie, GH Pitié Salpêtrière

Paris, France

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NCT05258396