RecruitingNot ApplicableNCT05258981
The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
Exploring the Relationship Between Advanced Multimodal Brain MRI Phenotypes, Genes and Cognitive Outcome in Adults With CHD
Sponsor
Boston Children's Hospital
Enrollment
225 participants
Start Date
Jul 1, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).
Eligibility
Min Age: 24 YearsMax Age: 35 Years
Inclusion Criteria2
- Persons who participated in the Boston circulatory arrest, pH and Hematocrit studies at Boston Childrens Hospital as children (n~300).
- Normally-developed age- and sex-matched young adults who are able to provide informed consent to undergo the MRI portion of the study and limited neuropsychological evaluation (IQ assessment as well as neuropsychological tests for which normative references are not available).
Exclusion Criteria3
- For controls - inability to complete the MRI (implanted metal, claustrophobia, personal history of mental illness, brain injury, prior brain intervention).
- Intellectual impairment precluding completion of the study questionnaires independently
- Unable to speak and read English fluently
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Interventions
DIAGNOSTIC_TESTMRI
Brain MRI
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05258981
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