RecruitingPhase 1NCT05259709

A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With Cemiplimab

A First-in-Human Study of 89Zr-DFO-REGN5054 (Anti-CD8) Positron Emission Tomography in Patients With Solid Malignancies Treated With Cemiplimab


Sponsor

Regeneron Pharmaceuticals

Enrollment

50 participants

Start Date

Feb 7, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study is researching an experimental drug called 89Zr-DFO-REGN5054 and cemiplimab. The study is focused on patients with a type of cancer that can be potentially imaged using 89Zr-DFO-REGN5054 and show special tumor features that may be important to the way the immune system fights cancer. The aim of the study is to study the safety and tolerability (how the body reacts to the drug) of the imaging agent 89Zr-DFO REGN5054. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drugs (which could make the study drugs less effective or could lead to side effects)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 89Zr˗DFO˗REGN5054 and a drug called cemiplimab for people with advanced solid tumor and metastatic solid tumor. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG89Zr˗DFO˗REGN5054

Administered by intravenous (IV) infusion during Part A and B.

DRUGcemiplimab

Administered by IV infusion every 3 weeks (Q3W).


Locations(1)

UMC Groningen

Groningen, Netherlands

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NCT05259709


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