Diffusion MRI of the Abdomen
Diffusion Magnetic Resonance Imaging (MRI) of the Abdomen
University of Wisconsin, Madison
80 participants
Nov 22, 2023
OBSERVATIONAL
Conditions
Summary
The purpose of this research is to see if a new magnetic resonance imaging (MRI) method will be able to improve the images taken of the abdomen. This new method includes some changes to help avoid movements that may disrupt the images like breathing, heartbeats and other involuntary motion that occurs in the abdomen. This study will these methods in healthy volunteers and validate them in patients with known liver metastases in a single contrast-enhanced MRI visit.
Eligibility
Inclusion Criteria5
- years of age or older
- years of age or older
- Patients with at least one of the following:
- Radiologically visible solid tumor liver metastasis, with at least one metastatic liver lesion must be a minimum of 8 mm in longest diameter
- Patients presenting for liver lesion biopsy
Exclusion Criteria11
- Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
- Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
- Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
- Patients with known contraindication to GBCA such as severe kidney disease or previously documented GFR < 30 ml/min/1.73 m2
- Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
- The subject has their own prescription for the medication.
- The informed consent process is conducted prior to the self-administration of this medication
- They come to the research visit with a driver
- Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
- Stent in bile ducts
- Partial hepatectomy
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Interventions
Diffusion-weighted (DW)-MRI has a unique ability to probe tissue microstructure without the need for ionizing radiation or intravenous contrast agents. DW-MRI of the abdomen is utilized in detection, staging, and treatment surveillance of malignancies, and has shown great promise in various other applications, including for the assessment of fibrosis in the liver, pancreas, kidneys, and other organs.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05261633