Fexofenadine in Patients With Active Rheumatoid Arthritis

This study is testing whether fexofenadine — a common allergy medication — can reduce inflammation and improve symptoms in people with moderate to severe rheumatoid arthritis (RA) that is not fully controlled by standard disease-modifying drugs. **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with moderate to severe rheumatoid arthritis (a disease activity score above 3.2) - You are currently being treated with standard disease-modifying anti-rheumatic drugs (DMARDs) but are not on biologic injections - You are willing to be randomly assigned to any treatment arm **You may NOT be eligible if...** - You have previously used or are currently using biologic drugs (such as adalimumab or etanercept) - You have active heart disease, liver disease, kidney disease, or severe lung disease (COPD) - You are allergic to fexofenadine or methotrexate - You drink alcohol heavily - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.