RecruitingPhase 2Phase 3NCT05267821

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS (TRIPS)

Sponsor

Nationwide Children's Hospital

Enrollment

500 participants

Start Date

Jun 14, 2022

Study Type

INTERVENTIONAL

Conditions

Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

Summary

The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).

Eligibility

Min Age: 1 DayMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Anakinra and a drug called Placebo for people with pediatric sepsis-induced multiple organ dysfunction syndrome (mods). The study is currently recruiting participants at 32 locations. People eligible for this study include aged 1 Day to 17 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAnakinra

See information in arm/group descriptions

DRUGPlacebo

See information in arm/group descriptions

Locations(32)

Children's of Alabama

Birmingham, Alabama, United States

Arkansas Children's Hospital

Little Rock, Arkansas, United States

Children's Hospital of Los Angeles

Los Angeles, California, United States

Benioff Children's Hospital - Oakland

Oakland, California, United States

Children's Hospital of Orange County

Orange, California, United States

University of California, Davis

Sacramento, California, United States

Rady Children's Hospital

San Diego, California, United States

Benioff Children's Hospital - Mission Bay

San Francisco, California, United States

Children's Hospital Colorado

Aurora, Colorado, United States

Children's National Medical Center

Washington D.C., District of Columbia, United States

Children's Hospital of Atlanta

Atlanta, Georgia, United States

Riley Children's Hospital

Indianapolis, Indiana, United States

CS Mott Children's Hospital

Ann Arbor, Michigan, United States

Children's Hospital of Michigan

Detroit, Michigan, United States

Children's Hospital of Minnesota

Minneapolis, Minnesota, United States

University of Minnesota

Minneapolis, Minnesota, United States

Mercy Children's Hospital

Kansas City, Missouri, United States

Duke University

Durham, North Carolina, United States

Akron Children's Hospital

Akron, Ohio, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Rainbow Babies and Children's Hospital

Cleveland, Ohio, United States

Nationwide Children's Hospital

Columbus, Ohio, United States

Pennsylvania State University

Hershey, Pennsylvania, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Medical University of South Carolina

Charleston, South Carolina, United States

University of Texas Southwestern

Dallas, Texas, United States

Texas Children's Hospital

Houston, Texas, United States

Children's Hospital of San Antonio

San Antonio, Texas, United States

Primary Children's Hospital

Salt Lake City, Utah, United States

Virginia Commonwealth University

Richmond, Virginia, United States

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

View Full Details on ClinicalTrials.gov

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NCT05267821