RecruitingNCT05271214

Conservative Management of Left Ventricular Assist Device Candidates

Sponsor

Tel-Aviv Sourasky Medical Center

Enrollment

100 participants

Start Date

Jan 1, 2018

Study Type

OBSERVATIONAL

Conditions

Advanced Heart Failure

Summary

Left ventricular assist device (LVAD) candidates will be comprehensively evaluated at our center, including clinical evaluation, echocardiography, right heart catheterization, cardiopulmonary exercise test and laboratory exams. following this evaluation, patients will be treated with inotropes, diuretics, uptitrated neurohormonal therapy. vitamin and iron deficiencies will be corrected and the patients will be referred for coronary interventions and cardiac resynchronization therapy appropriately. The need for LVAD implantation will be reevaluated according to the patient's clinical condition, echocardiography and laboratory findings.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether high-quality supportive (palliative) care is a viable alternative to a left ventricular assist device (LVAD) — a surgically implanted mechanical heart pump — for people with very advanced heart failure. **You may be eligible if...** - You have very advanced heart failure with a low ejection fraction (heart pumping less than 35%) - You have severe symptoms (New York Heart Association Class III or IV) - You have been hospitalized for heart failure in the past 6 months - You cannot tolerate standard heart failure medications - You have elevated BNP (a heart stress marker) and very low exercise capacity **You may NOT be eligible if...** - You are pregnant or unable to give informed consent - You have advanced liver disease - You have advanced kidney disease (eGFR below 30) - You have severe lung or peripheral vascular disease - You have an active cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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