RecruitingNot ApplicableNCT05273190

Stimulation of the Larynx to Treat Unexplained Chronic Cough

Vibrotactile Stimulation of the Larynx to Treat Unexplained Chronic Cough

Sponsor

University of Minnesota

Enrollment

60 participants

Start Date

Jul 13, 2021

Study Type

INTERVENTIONAL

Conditions

Cough

Summary

Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.

Eligibility

Min Age: 18 YearsMax Age: 88 Years

Inclusion Criteria5

Adults aged 18-88
\>8 weeks of cough
Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale
Ability to provide informed consent and independently complete questionnaires
Ability to read and speak English

Exclusion Criteria13

Electronic implants (e.g., pacemaker)
Currently doing speech therapy for cough
Contraindications to safe or effective VTS device use
No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis)
Untreated carotid disease
BMI \> 40 (for transmission of VTS through soft tissue)
Current or recent (quit \< 3 months ago) smoking
Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
History of known or suspected aspiration pneumonia
Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD)
Diagnosis or clinical suspicion of interstitial lung disease (ILD)
Unmanaged reflux
Unmanaged allergies/postnasal drip

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Interventions

DEVICEVibrotactile Stimulation

Small electric motors, similar to a vibrating cell phone or gaming joystick, deliver vibration to the throat. Participants will assess cough symptoms throughout the study period.