Recovery Rate in Secondary Hypothyroidism
Rate of Recovery of Secondary Hypothyroidism in Patients With Pituitary Disorders.
Nova Scotia Health Authority
90 participants
Apr 4, 2022
OBSERVATIONAL
Conditions
Summary
The aim of this project is to assess the rate of recovery of secondary hypothyroidism in patients with pituitary disorders.
Eligibility
Inclusion Criteria1
- Confirmed diagnosis of secondary hypothyroidism who are currently taking T4 replacement therapy
Exclusion Criteria4
- uncontrolled cardiovascular disease
- uncontrolled congestive heart failure
- uncontrolled mental health disorder
- not adequately replaced and have low T4 level.
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Interventions
Step 1: * Reduce the dose of T4 therapy by 50% and recheck serum T4 after 2 weeks. * If serum T4 is normal, go to step 2. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 2: * Discontinue T4 therapy altogether and recheck serum TSH and T4 after 2 weeks. * If serum T4 is normal, go to step 3. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 3: * Recheck serum TSH and T4 after 8 weeks. * If serum TSH and T4 levels are normal, these patients will be regarded as having successful T4 withdrawal. * If T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05276856