Standard Maintenance Therapy (SMT) vs Local Consolidative Radiation Therapy and SMT in OM-NSCLC

This study looks at whether adding targeted radiation therapy to standard maintenance treatment can improve outcomes for people with non-small cell lung cancer (NSCLC) that has spread to only a few spots in the body (called oligometastatic disease). After completing several cycles of standard systemic therapy without the cancer worsening, patients are randomly assigned to maintenance therapy alone or maintenance therapy plus targeted, high-dose radiation to all remaining disease sites. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with NSCLC that has spread to 1–5 sites in the body - You completed 4–6 cycles of standard systemic therapy without the cancer progressing - All spread sites are visible on imaging and suitable for high-dose radiation **You may NOT be eligible if...** - Your cancer progressed during initial therapy - Your cancer has a known driver gene mutation (such as EGFR or ALK) - You have more than 5 spread sites, or more than 3 in a single organ, or any lesion larger than 5 cm - You have cancer in the lining of the brain, spinal cord compression, or a serious heart or lung condition - You are pregnant Talk to your doctor to see if this trial is right for you.