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RecruitingNCT05278520

Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

Sponsor

University of Turku

Enrollment

110 participants

Start Date

Jan 11, 2023

Study Type

OBSERVATIONAL

Conditions

Rheumatoid ArthritisOsteoarthritis, Hip

Summary

The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.

Eligibility

Min Age: 18 YearsMax Age: 74 Years

Inclusion Criteria5

  • Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.
  • Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.
  • \----
  • Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.
  • \----

Exclusion Criteria3

  • The body mass index must be below 35
  • Age \< 18 or \> 74
  • The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.

Interventions

PROCEDURETotal hip arthroplasty

Hip joint replacement surgery. Elective for RA and OA cases.

Locations(4)

PET-centre, University of Turku

Turku, Southwest Finland, Finland

Turku Bioscience, University of Turku

Turku, Southwest Finland, Finland

Turku University Hospital

Turku, Southwest Finland, Finland

Helsinki University Hospital

Espoo, Uusimaa, Finland

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NCT05278520

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