Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

This study tests a non-invasive technique called sonobiopsy — using focused ultrasound waves through the skull — to detect tiny fragments of glioblastoma (brain tumor) DNA circulating in the blood. The goal is to develop a blood test that could diagnose or monitor this aggressive brain cancer without invasive procedures. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with a brain lesion that looks like glioblastoma on MRI (scan within 28 days) - The lesion is larger than 3 cm and located in the upper brain, near the surface - You are planning to have surgery to remove the tumor **You may NOT be eligible if...** - You cannot have an MRI (e.g., due to a pacemaker or metallic implants) - You have had previous brain surgery - You have a history of other cancers or cancer treatments - You have a blood clotting disorder - You have a skull defect or metal in your scalp Talk to your doctor to see if this trial is right for you.