Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

This study offers locally made CAR T-cell therapy — a cutting-edge treatment that re-engineers your own immune cells to attack cancer — for adults with B-cell lymphoma or B-cell acute lymphoblastic leukemia (B-ALL) who have already tried multiple other treatments. The cells are manufactured on-site rather than through commercial manufacturers. **You may be eligible if...** - You are 18–79 years old with B-cell lymphoma or B-ALL that has not responded to at least 2 prior treatments (1 prior treatment for B-ALL) - Your cancer expresses the CD19 protein on its surface - You are not eligible for (or cannot access) commercially available CAR T-cell therapy - Your heart and lung function are adequate, and your performance score is reasonably good **You may NOT be eligible if...** - You have active HIV, hepatitis B, or hepatitis C infection - You have active brain or spinal cord involvement by your cancer (unless previously treated and stable) - You have had a recent heart attack or serious active infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.