RecruitingNCT05284318

Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.

Effect of Antibiotic Treatment Course on Clinical Outcome After Two-stage Revision of Prosthetic Joint Infection: A Prospective Cohort Study.

Sponsor

First Affiliated Hospital of Fujian Medical University

Enrollment

500 participants

Start Date

Dec 1, 2021

Study Type

OBSERVATIONAL

Conditions

Anti-Bacterial Agents Periprosthetic Joint Infection

Summary

This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery. Eligible patients will be included in this study after signing the informed consent form. After the second stage revision, according to the patient's symptoms and examination results, the attending physician used a reasonable antibiotic treatment scheme (including intravenous and oral medication). All patients voluntarily participated in the study and signed informed consent. During the treatment period, all prospective patients underwent clinical evaluation at the time points of 1, 3, 6, 12, 18 and 24 months after the start of antibiotic treatment after phase II revision. The infection control rate of patients was evaluated by follow-up at least 2 years after operation, so as to analyze the effect of antibiotic treatment course after two-stage revision of periprosthetic joint infection.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at antibiotic treatment patterns and how well they work in patients who underwent a two-stage revision surgery for a joint infection (periprosthetic joint infection, or PJI) — a serious infection that develops around an artificial joint like a hip or knee replacement. You may be eligible if: - You are 18 years old or older - You were diagnosed with a joint infection (PJI) based on established criteria - You received a temporary spacer implant and completed at least 6 weeks of antibiotics - Your infection was deemed controlled and you underwent the second-stage joint revision - You provided informed consent You may NOT be eligible if: - Your follow-up data is not available - You are not able to comply with study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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