Spectroscopic MRI, Proton Therapy, and Avastin for Recurrent Glioblastoma

This study tests a combination of proton radiation therapy and bevacizumab (a drug that cuts off blood supply to tumors) for people with glioblastoma — the most aggressive type of brain tumor — that has come back after initial treatment. A special MRI technique (spectroscopic MRI) is used to better target the radiation to active tumor areas. **You may be eligible if...** - You are 18 or older with glioblastoma that has come back after standard treatment (surgery and radiation) - The tumor area is 6 cm or smaller on MRI - You completed your initial brain radiation at least 4–6 months ago (depending on where the tumor is located) - Your overall health and organ function are adequate **You may NOT be eligible if...** - You have previously received bevacizumab - Your tumor has come back in multiple separate areas across different parts of the brain - You have had a heart attack, stroke, or serious infection recently - You are pregnant or breastfeeding - Your tumor is in certain deep brain regions that would cause imaging errors (brainstem, cerebellum, orbitofrontal cortex) Talk to your doctor to see if this trial is right for you.