Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

This study offers premenopausal women with high-risk gene mutations (such as BRCA1, BRCA2, and related genes) an alternative to the standard preventive surgery of removing both the ovaries and fallopian tubes at once. Instead, they can choose to have only the fallopian tubes removed first (to reduce ovarian cancer risk) and delay removal of the ovaries until later, preserving hormonal function for longer. **You may be eligible if...** - You are a premenopausal woman aged 25–50 (age range varies by mutation type) - You carry a confirmed harmful mutation in BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, or PALB2 - You no longer want to use your fallopian tubes for natural conception (IVF plans are still allowed) - You still have at least one fallopian tube **You may NOT be eligible if...** - You are already postmenopausal - You have a personal history of ovarian, fallopian tube, or peritoneal cancer - You have had a bilateral salpingectomy (both fallopian tubes already removed) - You are legally unable to provide consent Talk to your doctor to see if this trial is right for you.