International Multicentric Study ARON-1
Hospital of Macerata
1,220 participants
Mar 10, 2022
OBSERVATIONAL
Conditions
Summary
The ARON-1 Study is designed as an International Multicentric Retrospective Study to collect global experiences with the use of immuno-combinations in patients with metastatic RCC. Two Supplementary Studies (ARON-1α and ARON-1β) have been designed. The ARON-1α Supplementary Study has been designed to investigate for the presence of genomic signatures from tumor samples of patients treated with first-line immuno-combinations for advanced RCC. The ARON-1β Supplementary Study has been designed to charaterize the immune cell populations and assess their relationship with the clinical outcome of mRCC patients treated with first-line immuno-combinations
Eligibility
Inclusion Criteria4
- Patients aged \>18y
- Cytological or Histologically confirmed diagnosis of clear cell or non-clear cell RCC
- Histologically or radiologically confirmed diagnosis of metastatic disease
- First-line treatment with nivolumab plus ipilimumab or nivolumab plus cabozantinib or pembrolizumab plus axitinib or pembrolizumab plus lenvatinib or avelumab plus axitinib or atezolizumab plus bevacizumab
Exclusion Criteria2
- Patients without histologically confirmed diagnosis of RCC
- Patients without histologically or radiologically confirmed metastatic disease
Interventions
collect global experiences with the use of immuno-combinations in patients with metastatic RCC
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05287464