Venetoclax Basket Trial for High Risk Hematologic Malignancies

This study tests venetoclax (a targeted cancer drug) in children, teenagers, and young adults with high-risk blood cancers including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) that is newly diagnosed or has come back after prior treatment. **You may be eligible if...** - You have been diagnosed with MDS or AML (including therapy-related forms) - You are 40 years old or younger (some sub-groups require age under 18) - Your cancer has high-risk features, has not responded to treatment, or has relapsed - Your organ function (heart, kidney, liver) is adequate for treatment **You may NOT be eligible if...** - You do not have a confirmed diagnosis of MDS or AML - You are over the age limit for your specific disease subgroup - You have another cancer requiring active treatment - You have serious infection or organ dysfunction Talk to your doctor to see if this trial is right for you.