RecruitingNot ApplicableNCT05296109

Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation

Application of 3D Magnetic Resonance Neurogram Sequences for Evaluation of Intraparotid Facial Nerves in Patients With Parotid Neoplasm


Sponsor

Chinese University of Hong Kong

Enrollment

50 participants

Start Date

Feb 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms. Within the parotid gland there are branches of the intra-parotid facial nerves, which are tiny in calibre and are prone to injury to injury during operation. It has been reported in recent retrospective view that the incidence of temporary and permanent facial nerve injury were 9.2% and 5.2% respectively, the risk of which increased with old age, malignant tumour and revision surgery. Traditional the incidental of facial nerve injury is reduced by intra-operative facial nerve monitoring and surgical magnification, while imaging has limited role in aiding this purpose. However with advancement in MRI technique high resolution three-dimensional sequences (i.e. neurogram sequences) are available for better visualization of branches of facial nerves. The investigators would therefore aim to demonstrate additional efficacy of these techniques and also to compare with conventional 3D post-contrast anatomical imaging studies in the localization and visualization of the facial nerve branches in patients with tumour. With better pre-operative imaging, the investigators hope to reduce the chance of facial nerve injury in these patients.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates whether a special 3D MRI technique can better visualize the facial nerve within the parotid gland (a saliva gland in the cheek area) in patients with parotid tumors. Accurate nerve mapping before surgery can reduce the risk of facial nerve damage during tumor removal. **You may be eligible if...** - You have been diagnosed with a tumor in your parotid gland (identified on ultrasound or CT scan) - You may or may not have already had a fine needle aspiration (a tissue sampling test) done - You are able to tolerate an MRI scan **You may NOT be eligible if...** - You have a pacemaker, metallic implants, or other devices incompatible with MRI - You have severe kidney failure or a prior serious allergic reaction to MRI contrast agents - You are unable to stay still for an MRI scan - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMagnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS)

The MRI examination will consist of both conventional sequences for diagnosis of salivary gland neoplasms (including DWI and DCE-MRI), together with additional neurogram sequences. (please refer to attached protocol for list of sequences)


Locations(1)

Gerald Choa MRI Center

Hong Kong, Hong Kong

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NCT05296109


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