RecruitingNCT05306327

Neurologic Physiology After Removal of Therapy (NeuPaRT)

Neurologic Physiology After Removal of Therapy (NeuPaRT): Pilot Multicentre Feasibility Study

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Enrollment

158 participants

Start Date

Oct 18, 2022

Study Type

OBSERVATIONAL

Conditions

Determination of Death

Summary

The purpose of this study is to determine when brain function stops compared to when the heart stops by monitoring electrical brain activity in patients who are taken off life support and progress to death in the intensive care unit.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age ≥ 18 years
Plan for the withdrawal of life sustaining measures (WLSM)
Attending physician anticipates patient will die within 24 hours of the withdrawal of life sustaining measures
Patient has an indwelling arterial cannula for monitoring blood pressure

Exclusion Criteria2

Brain death or plan for Neurologic Determination of Death (NDD)
Injuries that anatomically preclude the use of neurologic monitoring

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Interventions

DIAGNOSTIC_TESTelectroencephalography (EEG)

1. brain cortical activity using full scalp 2. cerebral blood flow velocity 3. during the dying process following planned withdrawal of life sustaining measures (WLSM)

Locations(5)

University of Calgary Foothills Campus

Calgary, Alberta, Canada

Kingston Health Sciences Centre

Kingston, Ontario, Canada

London Health Sciences Centre

London, Ontario, Canada

Ottawa Hospital

Ottawa, Ontario, Canada

Centre hospitalier de l'Université de Montréal,

Montreal, Quebec, Canada

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NCT05306327