RecruitingNot ApplicableNCT05307055

Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Theta Burst Subthalamic Nucleus Deep Brain Stimulation for Cognitive and Motor Improvements in Parkinson's Disease

Sponsor

University of Southern California

Enrollment

40 participants

Start Date

Jan 11, 2022

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a specific type of brain stimulation called "low frequency burst stimulation" affects thinking and memory in people with Parkinson's disease who already have a deep brain stimulator (DBS) implanted. DBS is a surgically implanted device that sends electrical signals to parts of the brain to reduce tremors and movement problems. **You may be eligible if...** - You have Parkinson's disease and already have a deep brain stimulator implanted on both sides of the brain (bilateral STN DBS) - You are over 18 years old - Your medications have been stable for at least 3 months - You are able to attend follow-up appointments and complete study tests **You may NOT be eligible if...** - You have a history of epilepsy or seizures - You have been diagnosed with dementia - You have a history of major substance abuse Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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