Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia

Exclusion Criteria15

• Combined with severe medical disease or liver or kidney dysfunction: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level elevates to 3 times or more of the upper limit of normal, kidney dysfunction (creatinine clearance < 30 mL/min)
• Patients are diagnosed with other malignant tumors of the reproductive system; patients with breast cancer or other hormone-dependent tumors that cannot be used with progesterone.
• Those who have received high doses of high potency progestin or oral contraceptives within the last 3 months (or those on maintenance medication).
• Those who require hysterectomy or other methods other than conservative treatment.
• Known or suspected pregnancy.
• Those who has contraindications to use progestin.
• Deep vein thrombosis, stroke, myocardial infarction.
• Severe joint lesions that prevent walking or movement.
• untreated or recurrent pelvic inflammatory disease (PID)
• an untreated or uncontrolled pelvic infection (vaginal, cervical, uterine);
• Cervical dysplasia
• Congenital or acquired uterine abnormalities, including uterine fibroid tumors or conditions that affect the shape of the uterus
• allergic to the LNG-IUS components
• uterine cavity is too large (average uterine diameter is over 7 cm) or have a history of LNG-IUS falling out.
• Notes: the last 6 criteria are only applied for patients with LNG-IUS.