RecruitingPhase 2Phase 3NCT05316493

Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia

Weight Management Plus Levonorgestrel Intrauterine System or Megestrol Acetate in Endometrial Atypical Hyperplasia: Multiple Single-arm, Prospective and Open-label Clinical Study

Sponsor

Xiaojun Chen

Enrollment

172 participants

Start Date

Jun 13, 2022

Study Type

INTERVENTIONAL

Conditions

Overweight and Obesity Atypical Endometrial Hyperplasia Fertility Issues

Summary

To investigate the efficacy of weight management plus levonorgestrel intrauterine system (LNG-IUS) or megestrol acetate (MA) in obese patients with endometrial atypical hyperplasia (EAH) asking for conservative therapy.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Intensive Lifestyle Intervention (ILI), a drug called Levonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg, and others for people with atypical endometrial hyperplasia, fertility issues, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include women aged 18 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALIntensive Lifestyle Intervention (ILI)

dietary guidance, exercise guidance, lifestyle intervention

DRUGMegestrol Acetate 160 MG Oral Tablet

enrolled participants will take Megestrol Acetate 160mg daily

DRUGLevonorgestrel-Releasing Intrauterine Contraceptive System (Mirena), 52 Mg

enrolled patients will be treated with LNG-IUS.

Locations(1)

Obstetrics and Gynecology Hospital of Fudan University

Shanghai, China

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NCT05316493

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