Regulation of Brain Glucose Metabolism in Type 1 Diabetes

This study investigates how the brain uses glucose (sugar) in people with type 1 diabetes who experience dangerous low blood sugar episodes they don't feel coming (hypoglycemia unawareness). Brain glucose metabolism may be altered in these patients, causing them to lose the normal warning signs of low blood sugar. **You may be eligible if...** - You have type 1 diabetes - You have a history of severe low blood sugar episodes (requiring someone else's help to recover) and/or hypoglycemia unawareness - OR you had at least 2 blood sugar readings below 54 mg/dL during 2 weeks of continuous glucose monitoring **You may NOT be eligible if...** - You are under 18 or over 55 years old - Your body weight is over 85 kg - Your BMI is over 30 kg/m² - You have untreated severe eye disease (proliferative retinopathy) - You have certain genetic conditions or other complications that would interfere with the study Talk to your doctor to see if this trial is right for you.