RecruitingNot ApplicableNCT05322967

Effect of Chronotherapy on Blood Pressure - Time of Intake of Blood Pressure Lowering Drugs

Chronotherapy in Hypertension - a Study of Blood Pressure Levels Following Intake of Antihypertensive Medication in the Morning or at Bedtime

Sponsor

Vastra Gotaland Region

Enrollment

120 participants

Start Date

Jun 25, 2022

Study Type

INTERVENTIONAL

Conditions

Hypertension Drug Therapy Primary Health Care

Summary

A randomized clinical trials with cross-over design to evaluate changes in blood pressure, renal function (creatinine, estimated glomerular filtration), LDL and HDL-cholesterol after taking antihypertensive drugs in the morning or at bedtime. Blood pressure will be estimated by ambulatory blood pressure measurements. There will be a shift in time of drug intake after 8 weeks for each participant. Approximately 100 individuals aged 40-75 years and on stable anti-hypertensive treatment and blood pressure \<150/95 mm Hg will be recruited. No new drugs will be introduced during the study.

Eligibility

Min Age: 40 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether taking blood pressure medication at a specific time of day (morning vs. evening) makes a difference in how well blood pressure is controlled over 24 hours, using a concept called chronotherapy. **You may be eligible if...** - You have high blood pressure (hypertension) - You are currently prescribed blood pressure medication - You are 18 or older - You are willing to use a 24-hour blood pressure monitor **You may NOT be eligible if...** - You have secondary hypertension (caused by another identifiable condition) - You have severe kidney or heart disease complicating medication timing - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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