Effect of Chronotherapy on Blood Pressure - Time of Intake of Blood Pressure Lowering Drugs
Chronotherapy in Hypertension - a Study of Blood Pressure Levels Following Intake of Antihypertensive Medication in the Morning or at Bedtime
Vastra Gotaland Region
120 participants
Jun 25, 2022
INTERVENTIONAL
Conditions
Summary
A randomized clinical trials with cross-over design to evaluate changes in blood pressure, renal function (creatinine, estimated glomerular filtration), LDL and HDL-cholesterol after taking antihypertensive drugs in the morning or at bedtime. Blood pressure will be estimated by ambulatory blood pressure measurements. There will be a shift in time of drug intake after 8 weeks for each participant. Approximately 100 individuals aged 40-75 years and on stable anti-hypertensive treatment and blood pressure \<150/95 mm Hg will be recruited. No new drugs will be introduced during the study.
Eligibility
Inclusion Criteria3
- Diagnosis of hypertension
- Stable antihypertensive treatment at least 8 weeks prior to inclusion
- One to four antihypertensive drugs
Exclusion Criteria8
- Atrial fibrillation/flutter
- Diabetes
- Previous stroke or TIA
- Heart failure
- Ischemic heart disease
- Peripheral artery disease
- Malignant disease with less than one year expected survival
- Inability to follow study protocol (for instance shift work)
Interventions
Time of ordinary antihypertensive medication intake
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT05322967