Patient Derived Preclinical Models
Mayo Clinic
50 participants
Apr 6, 2022
OBSERVATIONAL
Conditions
Summary
Study goal is to collect tumor specimens that may inform cancer biology to eventually improve outcomes for patients with cancer. This proposal represents a highly collaborative effort to support cancer research with the goal of developing novel therapeutic strategies using patient derived preclinical models. This study is being done to collect samples of tumor tissues, matched normal tissue when possible, and approximately 50 mL of blood.
Eligibility
Inclusion Criteria2
- years of age and older
- Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue
Exclusion Criteria9
- Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent
- Institutionalized or incarcerated patients
- Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use
- Biopsy must not be considered more than minimal risk to the patient.
- Have a contraindication to percutaneous biopsy including:
- Significant coagulopathy that cannot be adequately corrected.
- Severely compromised cardiopulmonary function or hemodynamic instability.
- Lack of a safe pathway to the lesion per the interventional radiologist.
- Inability of the patient to cooperate with, or to be positioned for, the procedure.
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Interventions
Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.
Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional
Buccal swab may be requested, if necessary, to generate germline data.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05324553