RecruitingNCT01143480

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin

Sponsor

National Institute of Environmental Health Sciences (NIEHS)

Enrollment

725 participants

Start Date

Jul 30, 2012

Study Type

OBSERVATIONAL

Conditions

Cancer Insulin Resistance Metabolic Syndrome Asthma Atherosclerosis

Summary

Background: \- Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: \- To examine how specific genes and proteins in blood cells respond to environmental exposures. Eligibility: \- Healthy volunteers between 18 and 45 years of age. Design: * The study will involve one visit of 45 to 60 minutes. * Participants will be screened with a brief physical examination and finger stick to determine if they are eligible to donate blood for the study, and will complete a questionnaire about any medications or other drugs (e.g., cigarettes) they may be taking. * Participants will provide a blood sample for research purposes.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study examines how a natural supplement called Innate (derived from yeast) affects the body's inflammatory response after a controlled exposure to a small amount of bacterial toxin (endotoxin), to understand how it might reduce harmful inflammation. **You may be eligible if...** - You are 18 years of age or older - You are generally healthy and able to perform normal daily activities - You are willing to fast overnight before your study visit - You are able to travel to the study site **You may NOT be eligible if...** - You have used anti-inflammatory pain relievers (like ibuprofen or naproxen) or acetaminophen (Tylenol) within the last 5 days - You have taken cholesterol-lowering drugs (statins) in the last 30 days - You are currently taking immune-suppressing medications - You are currently receiving chemotherapy or radiation for cancer - You have had a cold, respiratory illness, or stomach illness in the last 5 days - You have smoked or used tobacco/e-cigarettes in the last 2 weeks - You are pregnant - You weigh less than 50 kg (110 lbs) - You have chronic kidney disease or poorly controlled blood pressure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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