RecruitingNot ApplicableNCT05324579

Studying the Neuronal Basis of Human Social Cognition

An Integrated Single-neuronal, Population-, Local Network- and Stimulation-based Prefrontal Investigation of Human Social Cognition


Sponsor

Massachusetts General Hospital

Enrollment

20 participants

Start Date

May 20, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • 18 years old or older
  • patients able to give informed consent

Exclusion Criteria9

  • Children under 18
  • Significant co-morbidities
  • Claustrophobia or general anxiety that may impact intraoperative testing
  • Use of CNS-active medications including stimulants and antipsychotics which may alter
  • Pregnancy
  • Operative events that will require expedition of the surgery.
  • Poor tolerance of testing by the patient
  • Increased abnormal cortical excitability
  • Necessity to administer drugs that will interfere with mapping

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Interventions

BEHAVIORALBehavioral testing during neuronal recordings

Participants undergoing clinically planned neurosurgical procedures will undergo single-neuronal recordings as they perform brief behavioral tasks.


Locations(2)

Massachusetts General Hospital

Boston, Massachusetts, United States

Rhode Island Hospital

Providence, Rhode Island, United States

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NCT05324579


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