RecruitingNot ApplicableNCT05327322

Functional Outcomes From Diets in Multiple Sclerosis

The Impact of Diet Quality and Calorie Restriction on Physical Function and Patient Reported Outcomes in Multiple Sclerosis


Sponsor

University of Alabama at Birmingham

Enrollment

100 participants

Start Date

Mar 20, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test the effects of two dietary interventions, glycemic load and calorie restriction, on physical function, cognition, pain, fatigue, mood, and anxiety in adults with multiple sclerosis (MS). The investigators will also explore the how the diet interventions impact inflammation, immunity, and metabolic biomarkers.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing different diets to see which one best improves the daily functioning and quality of life of people with multiple sclerosis (MS) who are overweight or obese. **You may be eligible if...** - You have relapsing-remitting or secondary progressive MS - You have a BMI between 25 and 50 (overweight or obese) - You are able to walk at least 100 meters (with or without a mobility aid) - If you take MS medication, your dose has been stable for 6 months - You prepare your own meals or have significant input into what you eat **You may NOT be eligible if...** - You had an MS relapse in the last 30 days - You cannot walk 25 feet even with assistance - You are pregnant or breastfeeding - You use insulin or certain diabetes medications - You are already in a weight loss program Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALGlycemic load

Participants will be provided food to meet GL prescription for the duration of the trial.

BEHAVIORALCalorie restriction

Participants will be provided food to meet their prescribed daily calorie intake for the duration of the trial (weight stable in first 16 weeks, weight loss in second 16 weeks).

BEHAVIORALBehavioral support

All participants will receive behavioral supports in the form of email, text, information pages and weekly calls from the study staff to maximize adherence.


Locations(2)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Washington University

St Louis, Missouri, United States

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NCT05327322


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