LFMT vs Placebo in New Biologic Start for Ulcerative Colitis

This study is testing whether a stool transplant (fecal microbiota transplant, or FMT) given alongside a newly started biologic medication can improve outcomes for patients with active ulcerative colitis. **You may be eligible if...** - You are 18–74 years old - You have a confirmed diagnosis of active ulcerative colitis - Your disease extends at least 15 cm from the anal verge and has a total Mayo score of 6–12 - Your doctor has selected vedolizumab or ustekinumab as your new biologic treatment - You have not used other biologics, OR have not responded to prior biologics **You may NOT be eligible if...** - You are severely ill and require hospitalization - You have had recent abdominal surgery or a C. difficile infection in the past 4 weeks - You are pregnant or breastfeeding - You have recently used antibiotics or certain immunosuppressive medications - You have received FMT in the past 3 months Talk to your doctor to see if this trial is right for you.