RecruitingPhase 4NCT05331911

Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors

Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane


Sponsor

Kaohsiung Medical University Chung-Ho Memorial Hospital

Enrollment

500 participants

Start Date

Apr 26, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary Hepatocellular carcinoma. The study will enroll approximately 500 volunteers to compare the progression-free or overall survival in patients undergoing elective partial hepatectomy for primary liver tumors between propofol and sevoflurane for the maintenance of anesthesia.


Eligibility

Min Age: 20 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of general anesthesia — propofol (intravenous) versus sevoflurane (inhaled gas) — to see which one leads to better long-term outcomes in patients having part of their liver removed for liver cancer (hepatocellular carcinoma). **You may be eligible if...** - You are 20–80 years old - You are having surgery to remove part of your liver for hepatocellular carcinoma - Your general health falls within an acceptable surgical risk range (ASA class I–III) **You may NOT be eligible if...** - You have a severe mental disorder - You are pregnant or breastfeeding - You are severely obese - You have a known allergy to any anesthesia drugs used in the study - This is a repeat surgery or your tumor is recurrent - You are undergoing emergency surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPropofol

total intravenous anesthesia with propofol for the partial hepatectomy of hepatocellular carcinoma.

DRUGSevoflurane

The sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3% (target minimum alveolar concentration of 0.7-1.3 MAC).


Locations(1)

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

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NCT05331911


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