Lopinavir/Ritonavir in PLWH With High-Grade AIN

This study is testing whether lopinavir/ritonavir — an antiretroviral medication originally used for HIV — can treat high-grade anal dysplasia (a pre-cancerous condition of the anal canal) in people living with HIV. **You may be eligible if...** - You are 18 or older and living with HIV - You have been diagnosed with high-grade anal intraepithelial neoplasia (HGAIN), confirmed by biopsy - Your CD4 immune cell count is above 200 cells/mm³ - Your HIV is well-controlled on antiretroviral therapy **You may NOT be eligible if...** - You have only low-grade anal dysplasia - Your CD4 count is below 200 cells/mm³ - You are pregnant or breastfeeding - You are currently receiving chemotherapy or radiation for another cancer Talk to your doctor to see if this trial is right for you.