Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation

This study tests whether photobiomodulation therapy (a specialized light treatment applied inside the mouth) can prevent oral mucositis — painful sores in the mouth — that commonly develop in patients receiving intensive chemotherapy before a stem cell transplant. You may be eligible if: - You are 18 years old or older - You are planned to undergo myeloablative allogeneic hematopoietic cell transplantation (HCT) using FluBu4 conditioning with Tac-Mtx GVHD prevention - You are able to understand and sign informed consent You may NOT be eligible if: - You received intraoral photobiomodulation therapy within the past 4 weeks before your transplant admission - You have a history of radiation therapy to the head or neck - You have a history of photosensitivity or a disease causing photosensitivity - You are planned to receive palifermin for mouth sore prevention Talk to your doctor to see if this trial is right for you.