RecruitingPhase 1Phase 2NCT05336695

Assess Fibrin in Brains With AD/ADRD

Assess the Brain Levels of Fibrin in Alzheimer's Disease and Its Related Dementias Subjects Using 64Cu-FBP8 PET


Sponsor

Massachusetts General Hospital

Enrollment

30 participants

Start Date

Mar 29, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.


Eligibility

Min Age: 55 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is using brain MRI to look for fibrin — a blood-clotting protein — in the brains of people with Alzheimer's disease and related dementias (ADRD), to understand whether this protein plays a role in the disease. **You may be eligible if...** - You are between 55 and 90 years old - You can give informed consent - Healthy volunteers: no history of Alzheimer's or related memory disorders - People with ADRD: have a diagnosis of Alzheimer's disease with mild cognitive impairment to moderate dementia, with a memory test score of 15 or higher (MMSE) or 12 or higher (MoCA) **You may NOT be eligible if...** - You have a pacemaker, metal implants, or other MRI contraindications - You have claustrophobia or other conditions preventing an MRI scan - You have significant neurological conditions other than ADRD Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPET/MR Imaging

PET/MRI Scan with \[64Cu\]FBP8 as directed by protocol

DRUG64Cu-FBP8

Will be administered by intravenous injection by bolus by a qualified nuclear medicine technician at the Martinos Center


Locations(1)

Massachusetts General Hospital

Boston, Massachusetts, United States

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NCT05336695


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