RecruitingEarly Phase 1NCT05341492

EGFR/B7H3 CAR-T on Lung Cancer and Triple Negative Breast Cancer

A Single-arm, Open, Exploratory Clinical Study Evaluating the Safety and Efficacy of EGFR/B7H3 CAR-T in Patients With EGFR/ B7H3-positive Advanced Solid Tumors (Lung and Triple-negative Breast Cancer)


Sponsor

Second Affiliated Hospital of Guangzhou Medical University

Enrollment

30 participants

Start Date

May 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a single-arm, open, exploratory clinical study to evaluate the safety and efficacy of EGFR/B7H3 CAR-T in patients with EGFR/ B7H3-positive advanced solid tumors (lung cancer and triple-negative breast cancer)


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing CAR-T cell therapy targeting two proteins (EGFR and B7H3) in patients with advanced lung cancer or triple-negative breast cancer that has not responded to standard treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have advanced lung cancer or triple-negative breast cancer confirmed by biopsy - Your tumor tests positive for EGFR and/or B7H3 proteins on immunohistochemistry - Standard treatments including TKI drugs have failed - You have at least one measurable tumor lesion - Your expected survival is at least 12 weeks - Your ECOG performance status allows normal activity **You may NOT be eligible if...** - Your tumor does not express EGFR or B7H3 - Your organ function (liver, kidneys, heart) does not meet requirements - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALEGFR/B7H3 CAR-T

2 × 10\^6/kg CAR-T cells,For subjects with body weight greater than 60 kg, the number of cells can only be calculated according to 60 kg of body weight.


Locations(1)

Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

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NCT05341492