Protons Vs. Photons for High-risk Prostate Cancer

This study is comparing two types of radiation therapy — proton therapy and standard photon (X-ray) radiation — for men with high-risk or locally advanced prostate cancer. Both treatments target the same area, but proton therapy uses a different type of particle beam and may cause fewer side effects to nearby healthy tissue. **You may be eligible if...** - You are 18 or older with confirmed prostate cancer (stages T1 to T3b, no distant spread) - Your PSA is below 100 ng/mL - Your cancer requires treatment of the lymph nodes as well - You are generally healthy and have a life expectancy of at least 10 years - You have not previously been treated for prostate cancer **You may NOT be eligible if...** - You have hip replacements or other metal implants in the pelvic area (except small fiducial markers) - You have had major abdominal or rectal surgery - You have had another cancer in the past 5 years (except skin cancer) - You have inflammatory bowel disease - You are unable to understand or follow treatment instructions (including language barriers) Talk to your doctor to see if this trial is right for you.