RecruitingNot ApplicableNCT05350813

Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy

Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy in Pediatric Intensive Care Units : a Multicenter Randomized Controlled Trial

Sponsor

University Hospital, Toulouse

Enrollment

296 participants

Start Date

May 2, 2023

Study Type

INTERVENTIONAL

Conditions

Bacterial Infections

Summary

In this randomized controlled open-label trial, conducted in 7 French Pediatric and Neonatal Intensive Care Units (ICUs), investigator team hypothesize that the use of a procalcitonin (PCT)-guided algorithm to discontinue antibiotic treatment will decrease antibiotic duration in critically ill children treated for a suspected or proven bacterial infection. Two hundred and ninety-six eligible patients will be randomly assigned in two groups: either PCT-guided or standard-of-care antibiotic discontinuation, and monitored over 28 days, until the end of their hospitalization, or up to the end of antibiotic treatment for bacterial infection recurrence occurring up to 28 days after the day of randomization.

Eligibility

Min Age: 3 DaysMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Measurement of the PCT plasma levels and a procedure called Usual practice based on guidelines for people with bacterial infections. The study is currently recruiting participants at 8 locations. People eligible for this study include aged 3 Days to 17 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

PROCEDUREMeasurement of the PCT plasma levels

antibiotic treatment duration will be based on PCT plasma levels

PROCEDUREUsual practice based on guidelines

antibiotic therapy duration will be determined by the type of infection, microbiological results and clinical, biological and/or radiological evolution, according to the usual practice based on guidelines.