RecruitingPhase 4NCT05351229

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Intrathecal Morphine for Postoperative Analgesia in Video-Assisted and Robotic-Assisted Thoracic Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial

Sponsor

Northwestern University

Enrollment

90 participants

Start Date

Sep 29, 2023

Study Type

INTERVENTIONAL

Conditions

Pain, Postoperative

Summary

VATS/RATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS/RATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria3

Age 18-80 years old
Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection
General anesthesia with anticipated intraoperative extubation.

Exclusion Criteria17

American Society of Anesthesiologists (ASA) classification of 4 or 5
Anticipated postoperative intubation
Significant liver disease
Preoperative use of intravenous inotropes and/or vasopressor support
Preoperative mechanical ventilation
Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
Morphine allergy
Opioid or alcohol abuse
Chronic pain
Renal failure
Inability to comprehend English language
Bleeding disorder
Abnormal preoperative coagulation
Infection
Patient refusal
Failed spinal