Pain, Postoperative Clinical Trials

121 recruitingLast updated: June 17, 2026

There are 121 actively recruiting pain, postoperative clinical trials across 32 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 2, Early Phase 1, Phase 1. Top locations include New York, New York, United States, Istanbul, Turkey (Türkiye), Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Pain, Postoperative Trials at a Glance

121 actively recruiting trials for pain, postoperative are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 68 trials, with the heaviest enrollment activity in New York, Istanbul, and Boston. Lead sponsors running pain, postoperative studies include Peking University First Hospital, Başakşehir Çam & Sakura City Hospital, and Stanford University.

Browse pain, postoperative trials by phase

Treatments under study

About Pain, Postoperative Clinical Trials

Looking for clinical trials for Pain, Postoperative? There are currently 118 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pain, Postoperative trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pain, Postoperative clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 121 trials

Recruiting
Not Applicable

Comparison of the Rhomboid Intercostal Block and Serratus Posterior Superior Intercostal Plane Block

Pain, PostoperativeThoracic Surgery, Video-assistedMultimodal Analgesia+2 more
Ankara City Hospital Bilkent90 enrolled1 locationNCT07650877
Recruiting
Not Applicable

Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.

Pain, PostoperativeCesarean Section Complications
University of Calgary80 enrolled1 locationNCT06324942
Recruiting
Not Applicable

PENG Block + LIA For Endoprosthesis Surgery

anesthesia and analgesiaPain, PostoperativeNerve Block+3 more
ASST Gaetano Pini-CTO100 enrolled1 locationNCT07239817
Recruiting
Phase 4

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

Pain, PostoperativePharmacokinetics
Milton S. Hershey Medical Center40 enrolled1 locationNCT03737292
Recruiting
Phase 2

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

Pain, PostoperativeOsteoarthritis Thumb
Stanford University121 enrolled2 locationsNCT04676802
Recruiting
Phase 4

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Pain, Postoperative
Northwestern University90 enrolled1 locationNCT05351229
Recruiting
Not Applicable

Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial

SurgeryQuality of LifePain, Postoperative+5 more
CHU de Quebec-Universite Laval100 enrolled3 locationsNCT06884540
Recruiting
Not Applicable

Comparing Mindfulness-based Breath Training and Heart Rate Variability Biofeedback for Shoulder Surgery Patients in the Postoperative Pain.

Pain, PostoperativeShoulder Pain
Chang Gung Memorial Hospital120 enrolled1 locationNCT05917262
Recruiting
Not Applicable

Anesthetic Optimization in Pediatric LeFort Surgeries

Pain, PostoperativeLe Fort
Johns Hopkins University50 enrolled1 locationNCT05260320
Recruiting
Not Applicable

Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery

Pain, PostoperativeOpioid Use, Unspecified
University of Southern Denmark60 enrolled1 locationNCT05662371
Recruiting
Phase 2Phase 3

"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia

Opioid UsePain, PostoperativeLaparotomy
Sahiwal medical college sahiwal96 enrolled1 locationNCT07590752
Recruiting
Not Applicable

Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve Block

Pain, PostoperativeNerve BlockLower Extremity+1 more
Ataturk University60 enrolled1 locationNCT07550348
Recruiting
Not Applicable

Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques

Pain, PostoperativeNerve BlockOpioid Consumption, Postoperative+4 more
Başakşehir Çam & Sakura City Hospital52 enrolled1 locationNCT06821516
Recruiting
Not Applicable

Opioid-free Anaesthesia in Breast Cancer Surgery

Breast CancerPain, ChronicPain, Postoperative+3 more
University of Ioannina200 enrolled1 locationNCT06404983
Recruiting
Phase 4

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

Pain, PostoperativeSpine FusionLumbar Spine Degeneration+1 more
University of Southern California140 enrolled1 locationNCT05746143
Recruiting
Not Applicable

Promoting Sleep to Alleviate Pain - Arthroplasty

SurgeryPain, PostoperativeInsomnia+3 more
Uppsala University100 enrolled1 locationNCT06145516
Recruiting

Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery

Pain, PostoperativeCardiovascular DiseasesCardiovascular Surgical Procedures
Ordu University123 enrolled1 locationNCT07557108
Recruiting
Phase 3

Opioid-Free Orthopaedics

PainPain, Postoperative
Emory University80 enrolled3 locationsNCT04659317
Recruiting
Not Applicable

Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

Pain, Postoperative
Stony Brook University60 enrolled1 locationNCT06570577
Recruiting
Phase 3

Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

Opioid UsePain, PostoperativePain, Back+1 more
Hospital for Special Surgery, New York150 enrolled1 locationNCT05058287