STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation
STOPS Trial: A Multicentre Prospective Randomised Clinical Trial Comparing Total Colectomy With Ileorectal Anastomosis Versus Subtotal Colectomy With Cecal-rectal Anastomosis for Slow Transit Constipation
Third Military Medical University
252 participants
Mar 27, 2022
INTERVENTIONAL
Summary
Total colectomy with ileorectal anastomosis is a traditional surgical option for slow transit constipation (STC). Subtotal colectomy with caecorectal anastomosis have been reported to be a potential alternative approach. Thus, the optimal surgical option for STC is controversial.
Eligibility
Inclusion Criteria7
- Patients (≥18 years of age) of either sex
- Patients with conditions in agreement with the Roman IV criteria of functional constipation
- Patients have less than one complete spontaneous bowel movement per week
- Patients rely on laxatives to assist defecation for a long time
- More than 20% the radio-paque markers localized in the colon after 72 hours based on colonic transit studies
- Patients were refractory to conservative treatment for more than 1 year
- Patients with a strong desire for surgery
Exclusion Criteria8
- Pregnant or breast-feeding women
- Patients with megacolon, megarectum,severe spastic constipation, severe rectocele, rectal prolapse (Oxford Grade IV or above)
- Patients with colorectal neoplasms
- Patients with small intestinal slow transit
- Patients with constipation-predominant irritable bowel syndrome
- Patients with inflammatory bowel disease
- Patients with ileostomy
- Patients with severe psychiatric disease
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Interventions
Following complete colonic mobilization without preservation of the ileocolic vascular pedicle, the surgical specimen was extracted by extending the right lower quadrant trocar incision to approximately 4-5 cm. A resection of ileum, 2-3 cm proximal to the ileocecal junction, will be conducted by stapler. The anvil of a 29-mm circular stapler was inserted into the proximal ileal lumen and repositioned intra-abdominally. Ileorectal anastomosis was performed by transanal insertion of the circular stapler, aiming to achieve a tension-free, contamination-minimized reconstruction. Finally, a closed suction drain was placed in the rectouterine pouch (Douglas pouch), and all abdominal incisions were closed in layers.
Following complete colonic mobilization with preservation of the ileocolic vascular pedicle and its branches, the surgical specimen was extracted by extending the right lower quadrant trocar incision to 4-5 cm. After insertion of the anvil from a 29-mm circular stapler through the ascending colon resection margin, a resection about 3 cm distal to the ileocecal junction will be conducted. The cecum was then positioned in the pelvis without rotational torsion, and an antiperistaltic cecorectal anastomosis was created between cecal fundus (after appendectomy) and the rectal stump. The anastomosis was performed via transanal insertion of the circular stapler to ensure tension-free, contamination-controlled reconstruction. Finally, a closed suction drain was placed in the rectouterine pouch (Douglas pouch), and all abdominal incisions were closed in a layered fashion.
Locations(16)
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NCT05352074