Metastasis-directed Therapy for Oligorecurrent Prostate Cancer

This study is testing whether precisely targeting the specific sites where prostate cancer has returned (using radiation or other local therapies) delays the need to start hormone therapy in men with a small number of cancer recurrences after treatment. **You may be eligible if...** - You are 18 or older with a confirmed history of prostate cancer - Your primary tumor was previously treated and controlled - Your PSA is rising after surgery or radiation, indicating cancer has returned - You have 5 or fewer cancer spots visible on a PSMA PET scan - Your testosterone level is within the normal range **You may NOT be eligible if...** - You have more than 5 metastatic spots - Your testosterone is already at castrate (very low) levels, meaning you're already on hormone therapy - You have another active cancer besides prostate cancer - You have heart conditions that prevent you from taking enzalutamide (e.g., history of seizures or recent heart attack) - Previous treatments make new radiation therapy technically impossible Talk to your doctor to see if this trial is right for you.